Adam Hume

Work

Boston University Medical Campus

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Research Assistant Professor

US

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Boston University Medical Campus: Boston, MA, US

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Senior Research Scientist

US

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Boston University Medical Campus

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Research Scientist

US

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Boston University Medical Campus

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Postdoctoral Associate

US

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Education

University of Wisconsin Madison

United States of America
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PhD

Bates College

United States of America
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Bachelor of Science

Publications

Inhibitors of dihydroorotate dehydrogenase synergize with the broad antiviral activity of 4′-fluorouridine

Antiviral Research

journal-article

Harnessing Hazara Virus as a Surrogate for Crimean–Congo Hemorrhagic Fever Virus Enables Inactivation Studies at a Low Biosafety Level

Pathogens

journal-article

Harnessing Hazara Virus as a Surrogate for Crimean–Congo Hemorrhagic Fever Virus Enables Inactivation Studies at a Low Biosafety Level

Pathogens

journal-article

A Comparative Assessment of the Pathogenic Potential of Newly Discovered Henipaviruses

Pathogens

journal-article

Low-Input, High-Resolution 5′ Terminal Filovirus RNA Sequencing with ViBE-Seq

Viruses

journal-article

Low-Input, High-Resolution 5′ Terminal Filovirus RNA Sequencing with ViBE-Seq

Viruses

journal-article

Improved protein splicing through viral passaging

mBio

journal-article

Heat Inactivation of Nipah Virus for Downstream Single-Cell RNA Sequencing Does Not Interfere with Sample Quality

Pathogens

journal-article

Heat Inactivation of Nipah Virus for Downstream Single-Cell RNA Sequencing Does Not Interfere with Sample Quality

Pathogens

journal-article

A high-throughput, polymerase-targeted RT-PCR for broad detection of mammalian filoviruses

Microbiology Spectrum

journal-article

A Comparative Assessment of the Pathogenic Potential of Newly Discovered Henipaviruses

Pathogens

journal-article

Art of the Kill: Designing and Testing Viral Inactivation Procedures for Highly Pathogenic Negative Sense RNA Viruses

Pathogens

journal-article

Art of the Kill: Designing and Testing Viral Inactivation Procedures for Highly Pathogenic Negative Sense RNA Viruses

Pathogens

journal-article

Isolation and genome characterization of Lloviu virus from Italian Schreibers’s bats

Scientific Reports

journal-article

Establishment of an Inactivation Method for Ebola Virus and SARS-CoV-2 Suitable for Downstream Sequencing of Low Cell Numbers

Pathogens

journal-article

Establishment of an Inactivation Method for Ebola Virus and SARS-CoV-2 Suitable for Downstream Sequencing of Low Cell Numbers

Pathogens

journal-article

Minor intron–containing genes as an ancient backbone for viral infection?

PNAS Nexus

journal-article

Renaming of genera Ebolavirus and Marburgvirus to Orthoebolavirus and Orthomarburgvirus, respectively, and introduction of binomial species names within family Filoviridae

Archives of Virology

journal-article

Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes

Stem Cell Reports

journal-article

Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes

Stem Cell Reports

journal-article

Labeling Ebola Virus with a Self-Splicing Fluorescent Reporter

Microorganisms

journal-article

Labeling Ebola Virus with a Self-Splicing Fluorescent Reporter

Microorganisms

journal-article

Author Correction: Isolation of infectious Lloviu virus from Schreiber’s bats in Hungary

Nature Communications

journal-article

Author Correction: Isolation of infectious Lloviu virus from Schreiber’s bats in Hungary (Nature Communications, (2022), 13, 1, (1706), 10.1038/s41467-022-29298-1)

Nature Communications

journal-article

Author Correction: Isolation of infectious Lloviu virus from Schreiber’s bats in Hungary (Nature Communications, (2022), 13, 1, (1706), 10.1038/s41467-022-29298-1)

Nature Communications

journal-article

Isolation of infectious Lloviu virus from Schreiber’s bats in Hungary

Nature Communications

journal-article

Isolation of infectious Lloviu virus from Schreiber’s bats in Hungary

Nature Communications

journal-article

Isolation of infectious Lloviu virus from Schreiber’s bats in Hungary

Nature Communications

journal-article

Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection

American Journal of Physiology-Lung Cellular and Molecular Physiology

journal-article

Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection

American Journal of Physiology - Lung Cellular and Molecular Physiology

journal-article

Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection

American Journal of Physiology - Lung Cellular and Molecular Physiology

journal-article

Recombinant Lloviu virus as a tool to study viral replication and host responses

PLOS Pathogens

journal-article

Recombinant Lloviu virus as a tool to study viral replication and host responses

PLoS Pathogens

journal-article

Recombinant Lloviu virus as a tool to study viral replication and host responses

PLoS Pathogens

journal-article

A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV-2 at the immune–epithelial interface

Proceedings of the National Academy of Sciences

journal-article

A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV-2 at the immune–epithelial interface

Proceedings of the National Academy of Sciences of the United States of America

journal-article

A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV-2 at the immune–epithelial interface

Proceedings of the National Academy of Sciences of the United States of America

journal-article

Erratum: Recombinant Lloviu virus as a tool to study viral replication and host responses (PLoS Pathogens (2022) 18:2 (e1010268) DOI: 10.1371/journal.ppat.1010268)

PLoS Pathogens

journal-article

Erratum: Recombinant Lloviu virus as a tool to study viral replication and host responses (PLoS Pathogens (2022) 18:2 (e1010268) DOI: 10.1371/journal.ppat.1010268)

PLoS Pathogens

journal-article

Interferon-alpha or -beta facilitates SARS-CoV-2 pulmonary vascular infection by inducing ACE2

Angiogenesis

journal-article

Interferon-alpha or -beta facilitates SARS-CoV-2 pulmonary vascular infection by inducing ACE2

Angiogenesis

journal-article

The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters

bioRxiv

other

The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters

bioRxiv

other

Isolation and genome characterization of Lloviu virus from Italian Schreibers’ bent-winged bats

preprint

Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection

bioRxiv

other

Reservoir host studies of Lloviu virus: first isolation, sequencing and serology in Schreiber’s bats in Europe

other

Reservoir host studies of Lloviu virus: First isolation, sequencing and serology in Schreiber's bats in Europe

bioRxiv

other

Reservoir host studies of Lloviu virus: First isolation, sequencing and serology in Schreiber's bats in Europe

bioRxiv

other

Recombinant Lloviu virus as a model to study inaccessible zoonotic viruses

other

Recombinant Lloviu virus as a model to study inaccessible zoonotic viruses

bioRxiv

other

Recombinant Lloviu virus as a model to study inaccessible zoonotic viruses

bioRxiv

other

Human Pluripotent Stem Cell-Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response.

Stem cell reports

journal-article

Human Pluripotent Stem Cell-Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response

Stem Cell Reports

journal-article

Human Pluripotent Stem Cell-Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response

Stem Cell Reports

journal-article

A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV2 at the immune-epithelial interface

bioRxiv

other

Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection

bioRxiv

other

A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV2 at the immune-epithelial interface

bioRxiv

other

Ebola virus infection induces a type I interferon response and the shutdown of key liver functions in human iPSC-derived hepatocytes

ResearchSquare

other

Ebola virus infection induces a type I interferon response and the shutdown of key liver functions in human iPSC-derived hepatocytes

ResearchSquare

other

Erratum: Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2 (Molecular Cell (2020) 80(6) (1104–1122.e9), (S1097276520308285), (10.1016/j.molcel.2020.11.028))

Molecular Cell

journal-article

Erratum: Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2 (Molecular Cell (2020) 80(6) (1104–1122.e9), (S1097276520308285), (10.1016/j.molcel.2020.11.028))

Molecular Cell

journal-article

Human Pluripotent Stem Cell Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response

SSRN

other

Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2

Molecular Cell

journal-article

Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2

Molecular Cell

journal-article

Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2

Molecular Cell

journal-article

MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses

Science

journal-article

MHC class II transactivator CIITA induces cell resistance to ebola virus and SARS-like coronaviruses

Science

journal-article

MHC class II transactivator CIITA induces cell resistance to ebola virus and SARS-like coronaviruses

Science

journal-article

SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response.

Cell stem cell

journal-article

SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response

Cell Stem Cell

journal-article

SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response

Cell Stem Cell

journal-article

Egyptian Rousette IFN-ω Subtypes Elicit Distinct Antiviral Effects and Transcriptional Responses in Conspecific Cells

Frontiers in Immunology

journal-article

Egyptian Rousette IFN-ω Subtypes Elicit Distinct Antiviral Effects and Transcriptional Responses in Conspecific Cells

Frontiers in Immunology

journal-article

Egyptian Rousette IFN-ω Subtypes Elicit Distinct Antiviral Effects and Transcriptional Responses in Conspecific Cells

Frontiers in Immunology

journal-article

Human Pluripotent Stem Cell Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response

SSRN

other

Reconstructed signaling and regulatory networks identify potential drugs for SARS-CoV-2 infection

bioRxiv

other

Reconstructed signaling and regulatory networks identify potential drugs for SARS-CoV-2 infection

bioRxiv

other

SARS-CoV-2 infection of pluripotent stem cell-derived human lung alveolar type 2 cells elicits a rapid epithelial-intrinsic inflammatory response

bioRxiv

other

SARS-CoV-2 infection of pluripotent stem cell-derived human lung alveolar type 2 cells elicits a rapid epithelial-intrinsic inflammatory response

bioRxiv

other

SARS-CoV-2 spike protein interacts with multiple innate immune receptors

bioRxiv

other

SARS-CoV-2 spike protein interacts with multiple innate immune receptors

bioRxiv

other

Recent advances in marburgvirus research

F1000Research

journal-article

Recent advances in marburgvirus research [version 1; peer review: 3 approved]

F1000Research

journal-article

Recent advances in marburgvirus research [version 1; peer review: 3 approved]

F1000Research

journal-article

Ebolavirus polymerase uses an unconventional genome replication mechanism.

Proceedings of the National Academy of Sciences of the United States of America

journal-article

Ebolavirus polymerase uses an unconventional genome replication mechanism.

journal-article

Ebolavirus polymerase uses an unconventional genome replication mechanism

Proceedings of the National Academy of Sciences of the United States of America

journal-article

Ebolavirus polymerase uses an unconventional genome replication mechanism

Proceedings of the National Academy of Sciences of the United States of America

journal-article

Distinct Genome Replication and Transcription Strategies within the Growing Filovirus Family

Journal of Molecular Biology

journal-article

Distinct Genome Replication and Transcription Strategies within the Growing Filovirus Family

Journal of Molecular Biology

journal-article

Distinct Genome Replication and Transcription Strategies within the Growing Filovirus Family

Journal of Molecular Biology

journal-article

Recent advances in marburgvirus research [version 1; peer review: 3 approved]

journal-article

Marburg Virus Viral Protein 35 Inhibits Protein Kinase R Activation in a Cell Type-Specific Manner.

journal-article

Marburg Virus Viral Protein 35 Inhibits Protein Kinase R Activation in a Cell Type-Specific Manner

Journal of Infectious Diseases

journal-article

Marburg Virus Viral Protein 35 Inhibits Protein Kinase R Activation in a Cell Type-Specific Manner

Journal of Infectious Diseases

journal-article

The Egyptian Rousette Genome Reveals Unexpected Features of Bat Antiviral Immunity.

Cell

journal-article

The Egyptian Rousette Genome Reveals Unexpected Features of Bat Antiviral Immunity

Cell

journal-article

The Egyptian Rousette Genome Reveals Unexpected Features of Bat Antiviral Immunity.

journal-article

Toll-like receptor 4 in acute viral infection: Too much of a good thing.

PLoS pathogens

journal-article

Toll-like receptor 4 in acute viral infection: Too much of a good thing.

journal-article

Toll-like receptor 4 in acute viral infection: Too much of a good thing

PLoS Pathogens

journal-article

Toll-like receptor 4 in acute viral infection: Too much of a good thing

PLoS Pathogens

journal-article

A Chimeric Lloviu Virus Minigenome System Reveals that the Bat-Derived Filovirus Replicates More Similarly to Ebolaviruses than Marburgviruses.

Cell reports

journal-article

A Chimeric Lloviu Virus Minigenome System Reveals that the Bat-Derived Filovirus Replicates More Similarly to Ebolaviruses than Marburgviruses.

journal-article

A Chimeric Lloviu Virus Minigenome System Reveals that the Bat-Derived Filovirus Replicates More Similarly to Ebolaviruses than Marburgviruses

Cell Reports

journal-article

A Chimeric Lloviu Virus Minigenome System Reveals that the Bat-Derived Filovirus Replicates More Similarly to Ebolaviruses than Marburgviruses

Cell Reports

journal-article

The Egyptian Rousette Genome Reveals Unexpected Features of Bat Antiviral Immunity

Cell

journal-article

Marburg Virus Viral Protein 35 Inhibits Protein Kinase R Activation in a Cell Type-Specific Manner.

The Journal of infectious diseases

journal-article

Ebolaviruses Associated with Differential Pathogenicity Induce Distinct Host Responses in Human Macrophages.

journal-article

An RNA polymerase II-driven Ebola virus minigenome system as an advanced tool for antiviral drug screening.

Antiviral research

journal-article

An RNA polymerase II-driven Ebola virus minigenome system as an advanced tool for antiviral drug screening.

journal-article

An RNA polymerase II-driven Ebola virus minigenome system as an advanced tool for antiviral drug screening

Antiviral Research

journal-article

An RNA polymerase II-driven Ebola virus minigenome system as an advanced tool for antiviral drug screening

Antiviral Research

journal-article

Ebolaviruses Associated with Differential Pathogenicity Induce Distinct Host Responses in Human Macrophages.

Journal of virology

journal-article

Ebolaviruses associated with differential pathogenicity induce distinct host responses in human macrophages

Journal of Virology

journal-article

Ebolaviruses associated with differential pathogenicity induce distinct host responses in human macrophages

Journal of Virology

journal-article

Filovirus Strategies to Escape Antiviral Responses.

Current topics in microbiology and immunology

journal-article

Filovirus Strategies to Escape Antiviral Responses.

journal-article

Filovirus strategies to escape antiviral responses

Current Topics in Microbiology and Immunology

book-chapter

Filovirus strategies to escape antiviral responses

Current Topics in Microbiology and Immunology

book-chapter

Inactivation of RNA viruses by gamma irradiation: A study on mitigating factors

Viruses

journal-article

Inactivation of RNA viruses by gamma irradiation: A study on mitigating factors

Viruses

journal-article

Ebola Virus Does Not Induce Stress Granule Formation during Infection and Sequesters Stress Granule Proteins within Viral Inclusions.

journal-article

Ebola Virus Does Not Induce Stress Granule Formation during Infection and Sequesters Stress Granule Proteins within Viral Inclusions

Journal of Virology

journal-article

Ebola Virus Does Not Induce Stress Granule Formation during Infection and Sequesters Stress Granule Proteins within Viral Inclusions

Journal of Virology

journal-article

Ebola Virus Does Not Induce Stress Granule Formation during Infection and Sequesters Stress Granule Proteins within Viral Inclusions.

Journal of virology

journal-article

Inactivation of RNA Viruses by Gamma Irradiation: A Study on Mitigating Factors.

Viruses

journal-article

Inactivation of RNA Viruses by Gamma Irradiation: A Study on Mitigating Factors.

journal-article

Forty-Five Years of Marburg Virus Research

Viruses

journal-article

Forty-five years of marburg virus research

Viruses

journal-article

Forty-five years of Marburg virus research.

Viruses

journal-article

Forty-five years of Marburg virus research.

journal-article

Forty-five years of marburg virus research

Viruses

journal-article

Regulation of the retinoblastoma proteins by the human herpesviruses

Cell Division

journal-article

Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase.

Proceedings of the National Academy of Sciences of the United States of America

journal-article

Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase.

journal-article

Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase

Proceedings of the National Academy of Sciences of the United States of America

journal-article

Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase

Proceedings of the National Academy of Sciences of the United States of America

journal-article

Regulation of the retinoblastoma proteins by the human herpesviruses.

Cell division

journal-article

Regulation of the retinoblastoma proteins by the human herpesviruses.

journal-article

Regulation of the retinoblastoma proteins by the human herpesviruses

Cell Division

journal-article

Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function

Science

journal-article

Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function.

Science (New York, N.Y.)

journal-article

Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function.

journal-article

Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function

Science

journal-article

Early developmental 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure decreases chick embryo heart chronotropic response to isoproterenol but not to agents affecting signals downstream of the beta-adrenergic receptor

Toxicological Sciences

journal-article

Early developmental 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure decreases chick embryo heart chronotropic response to isoproterenol but not to agents affecting signals downstream of the beta-adrenergic receptor

Toxicological Sciences

journal-article

Early developmental 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure decreases chick embryo heart chronotropic response to isoproterenol but not to agents affecting signals downstream of the beta-adrenergic receptor.

Toxicological Sciences

journal-article

Early developmental 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure decreases chick embryo heart chronotropic response to isoproterenol but not to agents affecting signals downstream of the beta-adrenergic receptor.

journal-article